Ixcela Power

Product Details

Ixcela Power is specially formulated to support optimal levels of kynurenine, a metabolite that plays a critical role in the body’s inflammatory response. This supplement is especially helpful for individuals who have sluggish energy levels and/or significant amounts of physical, mental, or emotional stress.

If you are looking for an excellent source of B vitamins to support energy production, Ixcela Power is for you. Ixcela Power contains eight B vitamins plus choline and inositol to support the brain and nervous system, cellular energy, hormone production, and mood and cognitive function.*

Ixcela Power contains:

Vitamin B1 (as Thiamin HCI)
Vitamin B2 (Riboflavin)
Vitamin B3 (Niacin)
Vitamin B5 (Pantothenic Acid)
Vitamin B6 (as Pyridoxine Hydrochloride)
Vitamin B7 (Biotin)
Vitamin B9 (Folic Acid)
Vitamin B12 (as Cyanocobalamin)
Choline (DL Choline Bitartrate)
Inositol

As with any dietary supplement, consult your health care practitioner before using this product, especially if you are pregnant or nursing, anticipating surgery, taking any medications on a regular basis, or otherwise under medical supervision.

Ixcela supplements are formulated to exclude:

Gluten
Nuts
Preservatives
Corn

Wheat
Fish
Crustacean Shellfish
Added Colors

Soy
GMO
Dairy and Lactose
Eggs

Yeast
Sugars
Artificial Sweeteners

Ixcela supplements are produced at an FDA-registered, GMP-compliant facility and contain no harmful fillers. They are vegetarian and are not tested on animals.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Directions for Use

For adults only. Adults take one (1) tablet per day with a meal.

Warning: Keep out of reach of children.

Caution: As with any dietary supplement, consult your health care practitioner before using this product, especially if you are pregnant or nursing, anticipating surgery, taking any medications on a regular basis, or otherwise under medical supervision.

Storage: Keep tightly closed. Store in a dry place and avoid excessive heat.

Citations

B1

Dalgleish, C.E. “Thiamine and Tryptophan Metabolism.” Biochimica et Biophysica Aca, vol. 15, no. 2, 1954, pp. 295-296. https://doi.org/10.1016/0006-3002(54)90074-8.
(No authors listed). “Influence of Thiamine and Biotin on Tryptophan Metabolism.” Nutrition Reviews, vol. 14, no. 4, 1956, pp. 119-120. https://doi.org/10.1111/j.1753-4887.1956.tb01521.x.
Henderson, L.M., et al. “Effect of Deficiency of B Vitamins on the Metabolism of Tryptophan by the Rat.” Journal of Biological Chemistry, vol. 189, no. 1, 1951, pp. 19-29. http://www.jbc.org/content/189/1/19.full.pdf.

B2

Theofylaktopoulou, Despoina, et al. “Vitamins B2 and B6 as Determinants of Kynurenines and Related Markers of Interferon-γ-mediated Immune Activation in the Community-Based Hordaland Health Study.” British Journal of Nutrition, vol. 112, no. 7, 2014, pp. 1065-1072. https://doi.org/10.1017/S0007114514001858.
Marashly, E. and Bohlega, S. “Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine.” Frontiers in Neurology, vol. 8, no. 333, 2017. https://doi.org/10.3389/fneur.2017.00333.
Tsamaloukas, A. G. “Vitamins and Thrombosis (VITRO) Study—Homocysteine Lowering with B Vitamins.” Blood, vol. 109, no. 12, 2007, pp. 5520-5521. doi: https://doi.org/10.1182/blood-2007-01-066787.
Midttun, Øivind, et al. “Quantitative Profiling of Biomarkers Related to B-Vitamin Status, Tryptophan Metabolism and Inflammation in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry.” Rapid Communications in Mass Spectrometry, vol. 23, no. 9, 2009, pp. 1371-1379. https://doi.org/10.1002/rcm.4013.
Midttun, Øivind, et al. “Most Blood Biomarkers Related to Vitamin Status, One-Carbon Metabolism, and the Kynurenine Pathway Show Adequate Preanalytical Stability and Within-Person Reproducibility to Allow Assessment of Exposure or Nutritional Status in Healthy Women and Cardiovascular Patients.” The Journal of Nutrition, vol. 144, no. 5, 2014, pp. 784-790. https://doi.org/10.3945/jn.113.189738.
Aarsland, Tore, et al. “Serum Concentrations of Kynurenines in Adult Patients with Attention-Deficit Hyperactivity Disorder (ADHD): A Case–Control Study.” Behavioral and Brain Functions, vol. 11, no. 36, 2015. https://doi.org/10.1186/s12993-015-0080-x.
Myint, Aye. “Kynurenines: From the Perspective of Major Psychiatric Disorders .” FEBS Journal, vol. 279, no. 8, 2012, pp. 1375-1385. https://doi.org/10.1111/j.1742-4658.2012.08551.x.
Clayton, P.T., et al. “Pellagra with Colitis Due to a Defect in Tryptophan Metabolism.” European Journal of Pediatrics, vol. 150, 1991, pp. 498-502. https://doi.org/10.1007/BF01958432.
Dalgliesh, C.E. “Interrelationships of Tryptophan, Nicotinic Acid and Other B Vitamins.” British Medical Bulletin, vol. 12, no. 1, 1956, pp. 49-51. https://doi.org/10.1093/oxfordjournals.bmb.a069514.

B3

Makarov, M.V., et al. “The chemistry of the vitamin B3 metabolome.” Biochem Soc Trans. 2019 Feb 28;47(1):131-147. https://doi.org/10.1042/BST20180420.
Pissios, P. “Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme.” Trends Endocrinol Metab. 2017 May;28(5):340-353. https://doi.org/10.1016/j.tem.2017.02.004.
Doroftei, B., et al. “Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical Aspects.” Molecules. 2020 Jul 22;25(15):3323. https://doi.org/10.3390/molecules25153323.

B5

Tardy, A.L., et al. “Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence.” Nutrients. 2020 Jan 16;12(1):228. https://doi.org/10.3390/nu12010228.
Kennedy, D.O. “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review.” Nutrients. 2016 Jan 27;8(2):68. https://doi.org/10.3390/nu8020068.
Kunugi, H. and Mohammed Ali A. “Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans.” Int J Mol Sci. 2019 Sep 20;20(19):4662. https://doi.org/10.3390/ijms20194662.
Dietl, A.M., et al. “Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus.” Virulence. 2018;9(1):1036-1049. https://doi.org/10.1080/21505594.2018.1482181.

B6

Wolf, Hans. “Studies on Tryptophan Metabolism in Man: The Effect of Hormones and Vitamin B6 on Urinary Excretion of Metabolites of the Kynurenine Pathway: Part 1.” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 33, 1974, pp. 11-87. https://doi.org/10.3109/00365517409104201.
Wolf, Hans. “Studies on Tryptophan Metabolism in Man: The Effect of Hormones and Vitamin B6 on Urinary Excretion of Metabolites of the Kynurenine Pathway: Part 2.” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 33, 1974, pp. 89-182. https://doi.org/10.3109/00365517409104202.
Yess, Norma, et al. “Vitamin B6 Depletion in Man: Urinary Excretion of Tryptophan Metabolites.” The Journal of Nutrition, vol. 84, no. 3, 1964, pp. 229-236. https://doi.org/10.1093/jn/84.3.229.
Kowlessar, O. Dhodanand, et al. “Abnormal Tryptophan Metabolism in Patients with Adult Celiac Disease, with Evidence for Deficiency of Vitamin B6.” Journal of Clinical Investigation, vol. 43, no. 5, 1964, pp. 894-903. doi: 10.1172/JCI104975. https://dm5migu4zj3pb.cloudfront.net/manuscripts/104000/104975/JCI64104975.pdf.
Midttun, Øivind, et al. “Low Plasma Vitamin B-6 Status Affects Metabolism through the Kynurenine Pathway in Cardiovascular Patients with Systemic Inflammation.” The Journal of Nutrition, vol. 141, no. 4, 2011, pp. 611-617. https://doi.org/10.3945/jn.110.133082.
Rios-Avila, Luisa, et al. “A Mathematical Model of Tryptophan Metabolism via the Kynurenine Pathway Provides Insights into the Effects of Vitamin B-6 Deficiency, Tryptophan Loading, and Induction of Tryptophan 2,3-Dioxygenase on Tryptophan Metabolites.” The Journal of Nutrition, vol. 143, no. 9, 2013, pp. 1509-1519. https://doi.org/10.3945/jn.113.174599.
Rios-Avila, Luisa, et al. “Metabolite Profile Analysis Reveals Association of Vitamin B-6 with Metabolites Related to One-Carbon Metabolism and Tryptophan Catabolism but Not with Biomarkers of Inflammation in Oral Contraceptive Users and Reveals the Effects of Oral Contraceptives on These Processes.” The Journal of Nutrition, vol. 145, no. 1, 2015, pp. 87-95. https://doi.org/10.3945/jn.114.201095.
Hankes, L. V. et al. “Tryptophan Metabolism in Humans with Various Types of Anemias.” Blood, vol. 32, no. 4, 1968, pp. 649-661. https://doi.org/10.1182/blood.V32.4.649.649.
Deac, Oana, et al. “Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.” The Journal of Nutrition, vol. 146, no. 9, 2016, pp. 1801-1806. https://doi.org/10.3945/jn.116.230698.
Hansen, C.M., et al. “Vitamin B-6 Status of Women with a Constant Intake of Vitamin B-6 Changes with Three Levels of Dietary Protein.” The Journal of Nutrition, vol. 126, no. 7, 1996, pp. 1891-1901. https://academic.oup.com/jn/article/126/7/1891/4723639.
Majewski, M., et al. “Overview of the Role of Vitamins and Minerals on the Kynurenine Pathway in Health and Disease.” Journal of Physiology and Pharmacology, vol. 67, no. 1, 2016, pp. 3-19. https://www.ncbi.nlm.nih.gov/pubmed/27010891.
Ciorba, Matthew. “Kynurenine Pathway Metabolites: Relevant to Vitamin B-6 Deficiency and Beyond.” American Journal of Clinical Nutrition, vol. 98, no. 4, 2013, pp. 863-864. doi: 10.3945/ajcn.113.072025. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498264/pdf/ajcn984863.pdf.
Christensen, M.H.E., et al. “Inflammatory Markers, the Tryptophan-Kynurenine Pathway, and Vitamin B Status after Bariatric Surgery.” PLoS One, vol. 13, no. 2, 2018. doi: 10.1371/journal.pone.0192169. https://www.ncbi.nlm.nih.gov/pubmed/29401505.
Deac, Oana, et al. “Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults.” The Journal of Nutrition, vol. 145, no. 4, 2015, pp. 701-707. https://doi.org/10.3945/jn.114.203091.
Eastman, Clifford and Guilarte, Tomas. “Vitamin B-6, Kynurenines, and Central Nervous System Function: Developmental Aspects.” The Journal of Nutritional Biochemistry, vol. 3, no. 12, 1992, pp. 618-632. https://doi.org/10.1016/0955-2863(92)90081-S.
Danielski, L.G., et al. “Vitamin B6 Reduces Neurochemical and Long-Term Cognitive Alterations After Polymicrobial Sepsis: Involvement of the Kynurenine Pathway Modulation.” Molecular Neurobiology, vol. 55, no. 6, 2018, pp. 5255-5268. doi: 10.1007/s12035-017-0706-0. https://www.ncbi.nlm.nih.gov/pubmed/28879460.
Schaeffer, Monica C., et al. “Dietary Excess of Vitamin B-6 Affects the Concentrations of Amino Acids in the Caudate Nucleus and Serum and the Binding Properties of Serotonin Receptors in the Brain Cortex of Rats.” The Journal of Nutrition, vol. 128, no. 10, 1998, pp. 1829-1835. https://doi.org/10.1093/jn/128.10.1829.
Guilarte, Tomas. “Vitamin B6 and Cognitive Development: Recent Research Findings from Human and Animal Studies.” Nutrition Reviews, vol. 51, no. 7, 1993, pp. 193-198. https://doi.org/10.1111/j.1753-4887.1993.tb03102.x.

B7

Reininghaus, E.Z., et al. “PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression—A Randomized Controlled Trial.” Nutrients. 2020 Nov 8;12(11):3422. https://doi.org/10.3390/nu12113422.

Mock, D.M. “Biotin: From Nutrition to Therapeutics.” J Nutr. 2017 Aug;147(8):1487-1492. Epub 2017 Jul 12. https://doi.org/10.3945/jn.116.238956.

Lohr, K.M., et al. “Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.” Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33608-33618. Epub 2020 Dec 14. https://doi.org/10.1073/pnas.1922392117.

B9

Gomes, G.W., et al. “Effects of a Folic Acid 5 Mg Daily Intervention on Markers of Vitamin B Status and Kynurenine Pathway.” Blood, vol. 130, 2017, pp. 4793. https://ashpublications.org/blood/article/130/Supplement%201/4739/72100/Effects-of-a-Folic-Acid-5-Mg-Daily-Intervention-on.

B12

Lenti, G., et al. “Vitamin B12 among Vegetarians: Status, Assessment and Supplementation.” Nutrients. 2016 Nov 29;8(12):767. https://doi.org/10.3390/nu8120767.
Shipton, M.J. and Thachil, J. “Vitamin B12 deficiency - A 21st century perspective.” Clin Med (Lond). 2015 Apr;15(2):145-50. https://doi.org/10.7861/clinmedicine.15-2-145.
Romain, M., et al. “The role of Vitamin B12 in the critically ill—a review.” Anaesth Intensive Care. 2016 Jul;44(4):447-52. https://doi.org/10.1177/0310057X1604400410.
Health Quality Ontario. “Vitamin B12 and cognitive function: an evidence-based analysis.” Ont Health Technol Assess Ser. 2013 Nov 1;13(23):1-45. http://doi.org/10.1186/1471-2296-6-8
O'Leary, F. and Samman, S. “Vitamin B12 in health and disease.” Nutrients. 2010 Mar;2(3):299-316. Epub 2010 Mar 5. https://doi.org/10.3390/nu2030299.

Choline

Wiedeman, A.M., et al. “Dietary Choline Intake: Current State of Knowledge Across the Life Cycle.” Nutrients. 2018 Oct 16;10(10):1513. https://doi.org/10.3390/nu10101513.
Mun, J.G., et al. “Choline and DHA in Maternal and Infant Nutrition: Synergistic Implications in Brain and Eye Health.” Nutrients. 2019 May 21;11(5):1125. https://doi.org/10.3390/nu11051125.
Bekdash, R.A. “Neuroprotective Effects of Choline and Other Methyl Donors.” Nutrients. 2019 Dec 6;11(12):2995. https://doi.org/10.3390/nu11122995.

Inositol

Chatree, S., et al. “Role of Inositols and Inositol Phosphates in Energy Metabolism.” Molecules. 2020 Nov 1;25(21):5079. https://doi.org/10.3390/molecules25215079.
Genazzani, A.D. “Inositol as putative integrative treatment for PCOS.” Reprod Biomed Online. 2016 Dec;33(6):770-780. https://doi.org/10.1016/j.rbmo.2016.08.024.

Vitamin B Complex